Introduction to MDPHP

MDPHP (Methylenedioxy-α-pyrrolidinohexiophenone) is a synthetic stimulant that belongs to the cathinone and pyrrolidinophenone family. It is structurally related to α-PHP, α-PVP, and MDPV, compounds known for their strong dopaminergic and stimulant effects.

As a research chemical, MDPHP has gained attention for its high potency, long-lasting stimulation, and euphoria-inducing properties. This article explores its chemical profile, pharmacology, effects, research applications, and safety considerations.

Chemical Structure and Properties of MDPHP

MDPHP is classified as a synthetic cathinone and pyrrolidino stimulant.

Chemical Properties of MDPHP:

• CAS Number: 1387431-69-1
• PubChem CID: 137045672
• ChemSpider ID: 56389241
• UNII: ZP6LS2KVM7
• ChEMBL ID: ChEMBL5287491
• CompTox Dashboard (EPA): DTXSID80974352
• Formula: C17H23NO3
• Molar Mass: 289.37 g·mol⁻¹

Mechanism of Action and Pharmacological Effects

MDPHP is a potent central nervous system (CNS) stimulant that primarily affects dopamine and norepinephrine neurotransmitter systems.

How MDPHP Works:

• Dopamine Reuptake Inhibition – MDPHP blocks dopamine transporters (DAT), leading to an increase in dopamine levels, enhancing pleasure, motivation, and energy.
• Norepinephrine Enhancement – By increasing norepinephrine activity, it causes alertness, heightened focus, and increased heart rate.
• Serotonin Modulation – Some serotonergic activity contributes to mood enhancement and mild euphoria.

This mechanism is similar to α-PVP and MDPV, but MDPHP is often considered less potent than MDPV but stronger than 3-CMC or 2-MMC.

Effects of MDPHP

MDPHP produces powerful stimulant effects, including:

✔ Intense Stimulation – Increased energy, wakefulness, and focus.
✔ Euphoria & Mood Enhancement – Dopamine release creates pleasurable and rewarding sensations.
✔ Increased Motivation & Productivity – Cognitive enhancement effects.
✔ Elevated Heart Rate & Blood Pressure – A common effect of cathinones.

The onset of effects is typically within 10–30 minutes, lasting 4–8 hours, depending on dosage and metabolism.

Potential Research Applications of MDPHP

Since MDPHP is a research chemical, it has been studied for various scientific purposes:

1. Dopaminergic System Research

   • Used to study dopamine transporter interactions and stimulant pharmacology.

2. Cognitive Enhancement Studies

   • Analyzed for its potential to increase wakefulness and cognitive performance.

3. Comparison with Other Pyrrolidino Stimulants

   • Compared with α-PHP, α-PVP, and MDPV in terms of potency and duration.

Comparison with Other Stimulants

MDPHP is significantly stronger than 3-CMC and 2-MMC, with a higher potential for stimulation and euphoria.

Safety and Side Effects

Potential Side Effects of MDPHP:

• Elevated Heart Rate & Hypertension – Due to norepinephrine stimulation.
• Insomnia & Restlessness – Common with long-lasting stimulants.
• Anxiety & Paranoia – High doses may cause overstimulation or agitation.
• Reduced Appetite – Similar to other cathinones and stimulants.

Risk Factors & Considerations

• Potential for Neurotoxicity – Excessive dopamine release could lead to long-term receptor downregulation.
• High Abuse Potential – Like other pyrrolidinophenones, MDPHP has a strong reinforcing effect.
• Dangerous Interactions – Avoid combining with other stimulants, MAOIs, or alcohol due to potential cardiovascular stress.

Legal Status of MDPHP

The legal status of MDPHP varies worldwide. It is controlled in many countries under analog acts or cathinone regulations. Always check local laws before handling MDPHP for research purposes.

Conclusion

MDPHP is a potent stimulant research chemical with effects similar to MDPV, α-PHP, and other pyrrolidino-based cathinones. It is widely studied for its dopaminergic stimulation, cognitive enhancement, and energizing properties.

While MDPHP provides strong stimulant effects, it also comes with safety risks such as elevated heart rate, insomnia, and potential neurotoxicity. Researchers comparing 2-MMC, 3-CMC, and 5-MAPB may find MDPHP an intriguing subject for stimulant pharmacology studies.

For related compounds, check out:

• 2-MMC
• 3-CMC
• 5-MAPB